Synthesis of biomedical polyurethanes

Polyurethanes have been employed as biomaterials for several decades, because of their tunable mechanical properties, processability, and good biocompatibility. In our group, a library of biodegradable and bio-stable segmented polyurethanes has been synthesized and characterized. The introduction of soft segments of variable chemistry and composition leads to polymers exhibiting a diverse range of physical and chemical properties. Surface functionalization is achieved through the insertion of starting reagents bearing active functional groups, physical adsorption and through plasma technique.

“Biomimetic polyurethanes in nano and regenerative medicine”Susanna Sartori, Valeria Chiono, Chiara Tonda-Turo, Clara Mattu, Ciardelli Gianluca J. Mater. Chem. B, 2014, 2, 5128-5144.
“Synthesis and structure–property relationship of polyester-urethanes and their evaluation for the regeneration of contractile tissues” Susanna Sartori, Monica Boffito, Piero Serafini, Andrea Caporale, Antonella Silvestri, Ettore Bernardi, Maria Paola Sassi, Francesca Boccafoschi, Gianluca Ciardelli Reactive & Functional Polymers, Volume 73, Issue 10, 2013, Pages 1366–1376