Synthesis of biomedical polyurethanes

Polyurethanes have been employed as biomaterials for several decades, because of their tunable mechanical properties, processability, and good biocompatibility. In our group, a library of biodegradable and bio-stable segmented polyurethanes has been synthesized and characterized. The introduction of soft segments of variable chemistry and composition leads to polymers exhibiting a diverse range of physical and chemical properties. Surface functionalization is achieved through the insertion of starting reagents bearing active functional groups, physical adsorption and through plasma technique.

^{“Biomimetic polyurethanes in nano and regenerative medicine”Susanna Sartori, Valeria Chiono, Chiara Tonda-Turo, Clara Mattu, Ciardelli Gianluca J. Mater. Chem. B, 2014, 2, 5128-5144.}

^{“Synthesis and structure–property relationship of polyester-urethanes and their evaluation for the regeneration of contractile tissues” Susanna Sartori, Monica Boffito, Piero Serafini, Andrea Caporale, Antonella Silvestri, Ettore Bernardi, Maria Paola Sassi, Francesca Boccafoschi, Gianluca Ciardelli Reactive & Functional Polymers, Volume 73, Issue 10, 2013, Pages 1366–1376}